Trimethylsilyl cyanide → alpha-(3,4-Dimethylanilino)-alpha-(4-sulfamoylphenyl)acetonitrile

HRID 1415836Notes

Reaction equation

[CH3:1][C:2]1[CH:3]=[C:4]([CH:17]=[CH:18][C:19]=1[CH3:20])[N:5]=[CH:6][C:7]1[CH:12]=[CH:11][C:10]([S:13](=[O:16])(=[O:15])[NH2:14])=[CH:9][CH:8]=1.C[Si]([C:25]#[N:26])(C)C>>[CH3:1][C:2]1[CH:3]=[C:4]([CH:17]=[CH:18][C:19]=1[CH3:20])[NH:5][CH:6]([C:7]1[CH:8]=[CH:9][C:10]([S:13](=[O:16])(=[O:15])[NH2:14])=[CH:11][CH:12]=1)[C:25]#[N:26]

Participants

Reactant 2

HCID 82115Trimethylsilyl cyanide

HCID 21862755HCID 21862755, compound

Product 1

HCID 21862804alpha-(3,4-Dimethylanilino)-alpha-(4-sulfamoylphenyl)acetonitrile

Procedure

Following a procedure similar to that described in Example 1(ii), but using 3,4-dimethyl-N-(4-sulfamoylbenzylidene)aniline [prepared as described in step (i) above] and trimethylsilyl cyanide as starting materials, the title compound was obtained as a yellow powder (yield 100%).

Sources & evidence

ORD record: ord-08c67afe61a747f5b1e7d546551b997e
Source dataset: uspto-grants-1999_06
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05908858

Reaction notes

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