Trimethylsilyl cyanide → alpha-(3,5-Dimethylphenyl)-alpha-(4-sulfamoylanilino)acetonitrile

HRID 1415839Notes

Reaction equation

HRID 1415839 reaction equation
[CH3:1][C:2]1[CH:3]=[C:4]([CH:17]=[C:18]([CH3:20])[CH:19]=1)[CH:5]=[N:6][C:7]1[CH:12]=[CH:11][C:10]([S:13](=[O:16])(=[O:15])[NH2:14])=[CH:9][CH:8]=1.C[Si]([C:25]#[N:26])(C)C>>[CH3:20][C:18]1[CH:17]=[C:4]([CH:5]([NH:6][C:7]2[CH:12]=[CH:11][C:10]([S:13](=[O:16])(=[O:15])[NH2:14])=[CH:9][CH:8]=2)[C:25]#[N:26])[CH:3]=[C:2]([CH3:1])[CH:19]=1

Participants

3

Reactant 2

HCID 82115Trimethylsilyl cyanideHCID 21862765N-(3,5-Dimethylbenzylidene)-4-sulfamoylaniline

Product 1

HCID 21862823alpha-(3,5-Dimethylphenyl)-alpha-(4-sulfamoylanilino)acetonitrile

Procedure

Following a procedure similar to that described in Example 1(ii), but using N-(3,5-dimethylbenzylidene)-4-sulfamoylaniline [prepared as described in step (i) above] and trimethylsilyl cyanide as starting materials, the title compound was obtained as a pale yellow powder (yield 90%).

Sources & evidence

ORD record
ord-923eebdf92024134846edab7ba67a7b2
Source dataset
uspto-grants-1999_06
Patent number
US05908858

Reaction notes

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