HCID 53960015, compound → HCID 53780169, compound

HRID 1415882Notes

Reaction equation

HRID 1415882 reaction equation
[CH2:1]([C@@:5]1([CH2:24][CH3:25])[N:11]=[C:10]([C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)[C:9]2[CH:18]=[CH:19][C:20]([O:22][CH3:23])=[CH:21][C:8]=2[S:7][CH2:6]1)[CH2:2][CH2:3][CH3:4]>CCCCCC.CCOC(C)=O>[CH2:1]([C@@:5]1([CH2:24][CH3:25])[NH:11][C@H:10]([C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)[C:9]2[CH:18]=[CH:19][C:20]([O:22][CH3:23])=[CH:21][C:8]=2[S:7][CH2:6]1)[CH2:2][CH2:3][CH3:4]

Participants

3

Reactant 1

HCID 53960015HCID 53960015, compound

Product 1

HCID 53780169HCID 53780169, compoundYield 41.7%

Reagents, catalysts & solvents 1

HCID 21226206Ethyl acetate hexaneSolvent

Procedure

This compound was prepared following the procedure of Synthetic Example 1(n), using the product (54.4 g) from step (e). Chromatography on silica gel, using hexane:EtOAc (9:1) as eluant, gave the title product (22.8 g) as an orange oil. 1H NMR consistent with the proposed structure.

Workup

  1. customThis compound was prepared

Sources & evidence

ORD record
ord-65ad03af4caf4c90819cccd823eaa3e7
Source dataset
uspto-grants-1999_06
Patent number
US05910494

Reaction notes

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