反应详情

温度

40 °C

To a mixture of methyl 1-butyl-1H-indole-6-carboxylate, (2.1 g) in glacial acetic acid (25 mL) was added sodium cyanoborohydride (2.28 g). The mixture was heated at 40° C. for 3 h then cooled to room temperature, partitioned between water and ethyl acetate and the layers were separated. The organic layer was washed three times with brine, dried over anhydrous sodium sulfate and concentrated to give 1.64 g of the title compound: 1H NMR (CDCl3) δ 0.969, 1.43, 1.59, 2.99, 3.1, 3.4, 3.88, 7.07, 7.34.

1. temperaturethen cooled to room temperature
2. custompartitioned between water and ethyl acetate
3. customthe layers were separated
4. washThe organic layer was washed three times with brine
5. dry with materialdried over anhydrous sodium sulfate
6. concentrationconcentrated