Potassium Nitrate → HCID 22441109, compound

HRID 1415954Notes

Reaction equation

HRID 1415954 reaction equation
[Cl:1][C:2]1[N:11]=[C:10]2[C:5]([C:6](=[O:22])[C:7]([C:19]([OH:21])=[O:20])=[CH:8][N:9]2[C:12]2[CH:17]=[CH:16][C:15]([F:18])=[CH:14][CH:13]=2)=[CH:4][C:3]=1[F:23].[N+:24]([O-])([O-:26])=[O:25].[K+]>S(=O)(=O)(O)O>[Cl:1][C:2]1[N:11]=[C:10]2[C:5]([C:6](=[O:22])[C:7]([C:19]([OH:21])=[O:20])=[CH:8][N:9]2[C:12]2[CH:13]=[CH:14][C:15]([F:18])=[C:16]([N+:24]([O-:26])=[O:25])[CH:17]=2)=[CH:4][C:3]=1[F:23]

Participants

4

Reactant 2

HCID 24434Potassium NitrateHCID 13987857HCID 13987857, compound

Product 1

HCID 22441109HCID 22441109, compoundYield 64.7%

Reagents, catalysts & solvents 1

HCID 1118Sulfuric AcidSolvent

Conditions

Temperature
80 °C

Procedure

To 10 ml of conc. sulfuric acid was added 1.5 g of 7-chloro-6-fluoro-1-(4-fluorophenyl)-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic acid. Potassium nitrate (1.4 g) was added in portions to the solution, which was heated and stirred at 80° C. for 2 hours. The reaction solution was allowed to cool down, poured into ice water, and stirred overnight. The precipitated solid was collected by filtration and successively washed with water, ethanol, and diethyl ether to give 1.1 grams of the title compound.

Workup

  1. temperaturewas heated
  2. temperatureto cool down
  3. stirringstirred overnight
  4. filtrationThe precipitated solid was collected by filtration
  5. washsuccessively washed with water, ethanol, and diethyl ether

Sources & evidence

ORD record
ord-a4e9d5cb727e48cba265d5022402a170
Source dataset
uspto-grants-1999_06
Patent number
US05910498

Reaction notes

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