Potassium Nitrate → HCID 22441109, compound

Participants

Reaction Conditions

Reaction Steps

To 10 ml of conc. sulfuric acid was added 1.5 g of 7-chloro-6-fluoro-1-(4-fluorophenyl)-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic acid. Potassium nitrate (1.4 g) was added in portions to the solution, which was heated and stirred at 80° C. for 2 hours. The reaction solution was allowed to cool down, poured into ice water, and stirred overnight. The precipitated solid was collected by filtration and successively washed with water, ethanol, and diethyl ether to give 1.1 grams of the title compound.

Provenance & Evidence