Hydrochloric Acid → HCID 22440998, compound

HRID 1415962Notes

Reaction equation

HRID 1415962 reaction equation
[Cl:1][C:2]1[C:3]([F:28])=[C:4]([F:27])[CH:5]=[C:6]2[C:11]=1[N:10]([C:12]1[C:17]([F:18])=[CH:16][C:15]([F:19])=[CH:14][C:13]=1[F:20])[CH:9]=[C:8]([C:21]([O:23]CC)=[O:22])[C:7]2=[O:26].Cl>C(O)(=O)C>[Cl:1][C:2]1[C:3]([F:28])=[C:4]([F:27])[CH:5]=[C:6]2[C:11]=1[N:10]([C:12]1[C:13]([F:20])=[CH:14][C:15]([F:19])=[CH:16][C:17]=1[F:18])[CH:9]=[C:8]([C:21]([OH:23])=[O:22])[C:7]2=[O:26]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 53870011HCID 53870011, compound

Product 1

HCID 22440998HCID 22440998, compoundYield 67%

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

Ethyl 8-chloro-6,7-difluoro-1-(2,4,6-trifluorophenyl)-1,4-dihydro-4-oxoquinoline-3-carboxylate (1.2 g) was added to 5 ml of conc. hydrochloric acid and 1 ml of acetic acid. The solution was heated at reflux for 3 hours. The reaction solution was allowed to cool down whereupon the precipitated solid was collected by filtration and washed with ethanol and diethyl ether to give 750 mg of the title compound.

Workup

  1. temperatureThe solution was heated
  2. temperatureat reflux for 3 hours
  3. temperatureto cool down whereupon the precipitated solid
  4. filtrationwas collected by filtration
  5. washwashed with ethanol and diethyl ether

Sources & evidence

ORD record
ord-d866dded2871408c8a24ec1f84a9210a
Source dataset
uspto-grants-1999_06
Patent number
US05910498

Reaction notes

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