HuagongsheHuagongshe Chemistry Print Report · For research reference only
Trifluoroacetic acid → 1-(3-Amino-4,6-difluorophenyl)-7-(3-aminoethylazetidin-1-yl)-8-chloro-6-fluoro-1,4-dihydro-4-oxoquinoline-3-carboxylic acid trifluoroacetic acid salt
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | 1-(3-Amino-4,6-difluorophenyl)-8-chloro-6,7-difluoro-1,4-dihydro-4-oxoquinoline-3-carboxylic acid | HCID 10861999 | — |
| Reactant | 1,4-Dioxane hydrochloride | HCID 20443148 | — |
| Reactant | 3-(N-Boc)-(2-aminoethyl)azetidine | HCID 37818431 | — |
| Solvent | Triethylamine | HCID 8471 | — |
| Product | 1-(3-Amino-4,6-difluorophenyl)-7-(3-aminoethylazetidin-1-yl)-8-chloro-6-fluoro-1,4-dihydro-4-oxoquinoline-3-carboxylic acid trifluoroacetic acid salt | HCID 86754104 | — |
Reaction Steps
Reaction was carried out as in Example 231 except that 1-(3-amino-4,6-difluorophenyl)-8-chloro-6,7-difluoro-1,4-dihydro-4-oxoquinoline-3-carboxylic acid, 3-t-butoxycarbonylaminoethylazetidine, and triethylamine were used. For deprotection, trifluoroacetic acid was used rather than 4N hydrochloric acid/dioxane to give the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05910498 |
| Source dataset | uspto-grants-1999_06 |
| ORD ID | ord-bfff1cb4396e41b8b05fc19877645325 |
| Source note | uspto-grants-1999_06 |