HRID1415968

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID6422

未命名化合物

结构：Nc1cc(-n2cc(C(=O)O)c(=O)c3cc(F)c(F)c(Cl)c32)c(F)cc1F

HCID10861999

未命名化合物

HCID20443148

1,4-Dioxane hydrochloride

C4H9ClO2

HCID37818431

3-(N-Boc)-(2-aminoethyl)azetidine

C10H20N2O2

PRODUCTS

生成物

结构：NCCC1CN(c2c(F)cc3c(=O)c(C(=O)O)cn(-c4cc(N)c(F)cc4F)c3c2Cl)C1.O=C(O)C(F)(F)F

HCID86754104

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID8471

Triethylamine

C6H15N

PROCEDURE

实验过程

Reaction was carried out as in Example 231 except that 1-(3-amino-4,6-difluorophenyl)-8-chloro-6,7-difluoro-1,4-dihydro-4-oxoquinoline-3-carboxylic acid, 3-t-butoxycarbonylaminoethylazetidine, and triethylamine were used. For deprotection, trifluoroacetic acid was used rather than 4N hydrochloric acid/dioxane to give the title compound.

WORKUP

后处理

customReaction

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-bfff1cb4396e41b8b05fc19877645325
来源数据集: uspto-grants-1999_06
DOI: 10.6084/m9.figshare.5104873.v1
专利: US05910498
来源说明: uspto-grants-1999_06

反应 SMILES

[NH2:1][C:2]1[CH:3]=[C:4]([N:10]2[C:19]3[C:14](=[CH:15][C:16]([F:22])=[C:17](F)[C:18]=3[Cl:20])[C:13](=[O:23])[C:12]([C:24]([OH:26])=[O:25])=[CH:11]2)[C:5]([F:9])=[CH:6][C:7]=1[F:8].C(OC([NH:34][CH2:35][CH2:36][CH:37]1[CH2:40][NH:39][CH2:38]1)=O)(C)(C)C.[F:41][C:42]([F:47])([F:46])[C:43]([OH:45])=[O:44].Cl.O1CCOCC1>C(N(CC)CC)C>[F:41][C:42]([F:47])([F:46])[C:43]([OH:45])=[O:44].[NH2:1][C:2]1[CH:3]=[C:4]([N:10]2[C:19]3[C:14](=[CH:15][C:16]([F:22])=[C:17]([N:39]4[CH2:40][CH:37]([CH2:36][CH2:35][NH2:34])[CH2:38]4)[C:18]=3[Cl:20])[C:13](=[O:23])[C:12]([C:24]([OH:26])=[O:25])=[CH:11]2)[C:5]([F:9])=[CH:6][C:7]=1[F:8]