Back
HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1415971Generated: October 30, 2026

L-Glutamic acid, N-(4-(methylamino)benzoyl)-, 1,5-diethyl ester → Diethyl methotrexate

https://huagongshe.com/reaction/1415971

Reaction equation

Participants

RoleNameHCIDCharge
ReactantL-Glutamic acid, N-(4-(methylamino)benzoyl)-, 1,5-diethyl esterHCID 75413—
Reactant6-(Bromomethyl)-2-imino-2,3-dihydropteridin-4-amine--hydrogen bromide (1/1)HCID 12503242—
ProductDiethyl methotrexateHCID 94528—

Reaction Steps

reacting this 6-bromomethyl-2,4-diaminopteridine hydrobromide with diethyl N-[4-(N-methylamino)-benzoyl]glutamate to give diethyl methotrexate, and

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS05910588
Source datasetuspto-grants-1999_06
ORD IDord-c5b289f1dcab4fb8a4b9babb2c87a3a0
Source noteuspto-grants-1999_06