反应详情

A mixture of 143 g (1.0 mol) of 3-chloro-2-methylphenol, 139 g (1.1 mol) of benzyl chloride, 276 g (2.0 mol) of potassium carbonate and 680 g of methyl ethyl ketone (MEK) is heated under reflux with stirring. After 8 hours, a further 25 g (0.18 mol) of potassium carbonate are added and the mixture is then heated under reflux for a further 8 hours. The batch is filtered and the filter cake is washed with MEK. After working up by distillation, 206 g of 2-benzyloxy-6-chlorotoluene (b.p. 161 ° C., 3 mbar) are obtained as a pale yellow liquid in 99.6% purity (surface area % according to GC). This corresponds to a yield of 88.3% of theory.

1. temperatureis heated
2. temperatureunder reflux
3. temperaturethe mixture is then heated
4. temperatureunder reflux for a further 8 hours
5. filtrationThe batch is filtered
6. washthe filter cake is washed with MEK
7. distillationAfter working up by distillation, 206 g of 2-benzyloxy-6-chlorotoluene (b.p. 161 ° C., 3 mbar)
8. customare obtained as a pale yellow liquid in 99.6% purity (surface area % according to GC)