Water → HCID 54430977, compound

HRID 1416161Notes

Reaction equation

HRID 1416161 reaction equation
[CH3:1][O:2][CH2:3][CH2:4][NH2:5].O.[N+:7]([C:10]1[CH:19]=[C:18]2[C:13]([NH:14][C:15](=[O:21])[C:16](=[O:20])[NH:17]2)=[CH:12][C:11]=1[S:22](Cl)(=[O:24])=[O:23])([O-:9])=[O:8]>>[CH3:1][O:2][CH2:3][CH2:4][NH:5][S:22]([C:11]1[CH:12]=[C:13]2[C:18](=[CH:19][C:10]=1[N+:7]([O-:9])=[O:8])[NH:17][C:16](=[O:20])[C:15](=[O:21])[NH:14]2)(=[O:23])=[O:24]

Participants

4

Reactant 3

HCID 962WaterHCID 80182-MethoxyethylamineHCID 54433101HCID 54433101, compound

Product 1

HCID 54430977HCID 54430977, compoundYield 59%

Procedure

To a solution of 3.76 g (0.05 mole) of 2-methoxyethylamine in 15 ml of water 6.11 g (0.02 mole) of 1,2,3,4-tetrahydro-7-nitro-2,3-dioxo-6-quinoxalinesulfonyl chloride are added at room temperature, under stirring. The mixture is stirred at room temperature for 6 hours and then allowed to stand for 16 hours. The separated crystals are filtered off, washed successively with water and acetone, filtered again, dried and dissolved in a slight amount of hot dimethyl sulfoxide. The product is precipitated from this solution with water. Thus 4.05 g (59%) of 1,2,3,4-tetrahydro-N-(2-methoxy-ethyl)-7-nitro-2,3-dioxo-6-quinoxaline sulfonamide are obtained, m.p.: 320-321° C.

Workup

  1. stirringThe mixture is stirred at room temperature for 6 hours
  2. filtrationThe separated crystals are filtered off
  3. washwashed successively with water and acetone
  4. filtrationfiltered again
  5. customdried
  6. dissolutiondissolved in a slight amount of hot dimethyl sulfoxide
  7. customThe product is precipitated from this solution with water

Sources & evidence

ORD record
ord-206c15ded7914c40bf7f4bb9fe64234b
Source dataset
uspto-grants-1999_06
Patent number
US05912245

Reaction notes

Loading…