反应详情

2-Amino-5-mercapto-1,3,4-thiadiazole (13.3 g), diethylaminoethylchloridehydrochloride (17.2 g), and potassium hydroxide (11.2 g) were stirred in methanol (200 ml) overnight at room temperature. The reaction mixture was concentrated under a vacuum. The residue, with water added thereto, was extracted with ethyl acetate. The extract was dried over sodium sulfate anhydride, and then concentrated under a vacuum. The resulting solid was recrystallized from n-hexane/ethanol, thereby yielding 19.0 g of the aimed compound.

1. concentrationThe reaction mixture was concentrated under a vacuum
2. additionThe residue, with water added
3. extractionwas extracted with ethyl acetate
4. dry with materialThe extract was dried over sodium sulfate anhydride
5. concentrationconcentrated under a vacuum
6. customThe resulting solid was recrystallized from n-hexane/ethanol