1-Chloro-2-(diethylamine)ethane hydrochloride → 5-{[2-(Diethylamino)ethyl]sulfanyl}-1,3,4-thiadiazol-2-amine

Participants

Reaction Steps

2-Amino-5-mercapto-1,3,4-thiadiazole (13.3 g), diethylaminoethylchloridehydrochloride (17.2 g), and potassium hydroxide (11.2 g) were stirred in methanol (200 ml) overnight at room temperature. The reaction mixture was concentrated under a vacuum. The residue, with water added thereto, was extracted with ethyl acetate. The extract was dried over sodium sulfate anhydride, and then concentrated under a vacuum. The resulting solid was recrystallized from n-hexane/ethanol, thereby yielding 19.0 g of the aimed compound.

Provenance & Evidence