反应详情

温度

100 °C

A mixture of 4-fluorobenzamide (Aldrich; 2.432 g), (RS)-2-methylpiperazine (Aldrich; 4.247 g), and water (9 mL) is heated at 100° C. for 7 days. The mixture is then cooled to 41° C. and water is added. The solid is collected, washed with water and toluene and dried under reduced pressure to give 3.37 g of (RS)-4-(3-methylpiperazin-1-yl)benzamide; 1H NMR (CDCl3, CD3OD) δ1.17, 2.48, 2.82, 2.94-3.15, 3.04, 3.68, 6.89, 7.73.

1. temperatureThe mixture is then cooled to 41° C.
2. customThe solid is collected
3. washwashed with water and toluene
4. customdried under reduced pressure