Potassium Hydroxide → Lamotrigine

HRID 1416365Notes

Reaction equation

HRID 1416365 reaction equation
[Cl:1][C:2]1[C:7]([Cl:8])=[CH:6][CH:5]=[CH:4][C:3]=1/[C:9](=[N:13]\[NH:14][C:15]([NH2:17])=[NH:16])/[C:10]([NH2:12])=O.[OH-].[K+]>C(O)C>[CH:5]1[CH:6]=[C:7]([Cl:8])[C:2]([Cl:1])=[C:3]([C:9]2[N:13]=[N:14][C:15]([NH2:17])=[N:16][C:10]=2[NH2:12])[CH:4]=1

Participants

4

Reactant 2

HCID 14797Potassium HydroxideHCID 178513162HCID 178513162, compound

Product 1

HCID 3878Lamotrigine

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

(E)-2-(2',3'-dichlorophenyl)-2-(guanidinylimino)acetamide (2.5 g) was dissolved in hot ethanol (40 ml). Potassium hydroxide (2.0 g, equivalent to 5% w/v) was added and the solution was irradiated by exposure to bright sunlight and a tungsten lamp (15W).

Sources & evidence

ORD record
ord-c579767fb383410b93f43bcacd771300
Source dataset
uspto-grants-1999_06
Patent number
US05912345

Reaction notes

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