反应详情

Concentrated hydrochloric acid (24.0 mL) was gradually dropped into 350 mL of an aqueous solution containing 27.5 g of diethyl iminodiacetate and 23.3 g of potassium cyanate. After stirring at room temperature for 18 hours, the reaction mixture was concentrated in vacuo. The residue was extracted with ethyl acetate several times and the extracts were combined followed by drying over sodium sulfate. The dried extract was concentrated and the residue was recrystallized from ethanol to give 11.1 g of ethyl 2,4-dioxoimidazolidine-1-acetate as white crystals.

1. concentrationthe reaction mixture was concentrated in vacuo
2. extractionThe residue was extracted with ethyl acetate several times
3. dry with materialby drying over sodium sulfate
4. extractionThe dried extract
5. concentrationwas concentrated
6. customthe residue was recrystallized from ethanol