Dimethylformamide → HCID 178437927, compound

HRID 1416417Notes

Reaction equation

HRID 1416417 reaction equation
CN(C)C=O.Cl.[CH2:7]([C:9]1[S:13][C:12](=[NH:14])[N:11]([CH2:15][C:16]2[CH:21]=[CH:20][C:19]([C:22]3[CH:27]=[CH:26][CH:25]=[CH:24][C:23]=3[C:28]3[NH:32][N:31]=[N:30][N:29]=3)=[CH:18][CH:17]=2)[N:10]=1)[CH3:8].[C:33]12[C:41](=[O:42])[O:40][C:38](=[O:39])[C:34]=1[CH2:35][CH2:36][CH2:37]2>O>[CH2:7]([C:9]1[S:13][C:12](=[N:14][C:41]([C:33]2[CH2:37][CH2:36][CH2:35][C:34]=2[C:38]([OH:40])=[O:39])=[O:42])[N:11]([CH2:15][C:16]2[CH:17]=[CH:18][C:19]([C:22]3[CH:27]=[CH:26][CH:25]=[CH:24][C:23]=3[C:28]3[NH:29][N:30]=[N:31][N:32]=3)=[CH:20][CH:21]=2)[N:10]=1)[CH3:8]

Participants

5

Reactant 3

HCID 6228DimethylformamideHCID 3248541H,3H,4H,5H,6H-cyclopenta(c)furan-1,3-dioneHCID 178437931HCID 178437931, compound

Product 1

HCID 178437927HCID 178437927, compoundYield 67.8%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

To 2 ml of N,N-dimethylformamide, 200 mg of 5-ethyl-2-imino-3-[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl-1,3,4-thiadiazoline hydrochloride and 76 mg of 1-cyclopentene-1,2-dicarboxylic anhydride were added and the resulting mixture was stirred at room temperature for 2 hours. Water was added to the reaction mixture and the crystals so precipitated were collected by filtration. The crystals were washed with water and ethanol and then dried, whereby 170 mg of the title compound was obtained.

Workup

  1. customthe crystals so precipitated
  2. filtrationwere collected by filtration
  3. washThe crystals were washed with water and ethanol
  4. customdried

Sources & evidence

ORD record
ord-bc686ad5b3314892ba70df5eda802127
Source dataset
uspto-grants-1999_06
Patent number
US05912353

Reaction notes

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