Methyl 4-(pyridin-2-YL)benzoate → 4-(2-Pyridyl)Benzoic Acid

HRID 1416424ノート

反応式

HRID 1416424 の反応式
C[O:2][C:3](=[O:16])[C:4]1[CH:9]=[CH:8][C:7]([C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][N:11]=2)=[CH:6][CH:5]=1>CO.[OH-].[Na+]>[N:11]1[CH:12]=[CH:13][CH:14]=[CH:15][C:10]=1[C:7]1[CH:8]=[CH:9][C:4]([C:3]([OH:16])=[O:2])=[CH:5][CH:6]=1

参加物

4

反応物 1

HCID 3358924Methyl 4-(pyridin-2-YL)benzoate

生成物 1

HCID 8216924-(2-Pyridyl)Benzoic Acid

試薬・触媒・溶媒 2

HCID 887Methanol溶媒HCID 14798Sodium Hydroxide溶媒

実験手順

12.85 g (60.2 mmol) of 4-(pyridin-2-yl)-benzoic acid methyl ester in 125 ml of methanol and 67 ml of 1N sodium hydroxide solution are stirred at room temperature for 6 h. The resulting solution is partially concentrated by evaporation; the aqueous residue is extracted with ethyl acetate and acidified to pH≈1.5 with 2N HCl solution. The title compound precipitates out and can be filtered off and washed with water: TLC (ethyl acetate): Rf =0.35; FAB MS (M+H)+ =200.

後処理

  1. concentrationThe resulting solution is partially concentrated by evaporation
  2. extractionthe aqueous residue is extracted with ethyl acetate
  3. customThe title compound precipitates out and
  4. filtrationcan be filtered off
  5. washwashed with water

出典と根拠

ORDレコード
ord-3ad5a9fff1bb49b4aac06329a545dc65
出典データセット
uspto-grants-1999_06
特許番号
US05912352

反応ノート

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