Acetone → HCID 67581944, compound

HRID 1416449Notes

Reaction equation

HRID 1416449 reaction equation
[OH:1][C@H:2]1[CH2:6][CH2:5][CH2:4][C@@H:3]1[O:7][C:8]1[C:17]2[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=2)[N:11]=[C:10]([N:18]2[CH2:23][CH2:22][NH:21][CH2:20][CH2:19]2)[N:9]=1.CC(C)=[O:26]>>[C:8]([OH:26])(=[O:7])[CH3:17].[OH:1][C@H:2]1[CH2:6][CH2:5][CH2:4][C@@H:3]1[O:7][C:8]1[C:17]2[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=2)[N:11]=[C:10]([N:18]2[CH2:19][CH2:20][NH:21][CH2:22][CH2:23]2)[N:9]=1

Participants

3

Reactant 2

HCID 180AcetoneHCID 15409124HCID 15409124, compound

Product 1

HCID 67581944HCID 67581944, compound

Procedure

4-[(1S,2S)-(2-Hydroxycyclopentan-1-yl)oxy]-2-(1-piperazinyl)quinazoline (cf. Example 5) (1.03 g) is dissolved in acetone (35 ml) with heating, and the solution is filtered, and to the filtrate is added acetic acid (0.20 ml), and the mixture is allowed to stand at room temperature. The precipitated crystals are separated by filtration to give 4-[(1S,2S)-(2-hydroxycyclopentan-1-yl)oxy]-2-(1-piperazinyl)quinazoline monoacetate (990 mg) as crystals.

Workup

  1. temperaturewith heating
  2. filtrationthe solution is filtered
  3. additionto the filtrate is added acetic acid (0.20 ml)
  4. customto stand at room temperature
  5. customThe precipitated crystals are separated by filtration

Sources & evidence

ORD record
ord-91a43d6fdf924e69b7d961aead5d63bb
Source dataset
uspto-grants-1999_06
Patent number
US05912247

Reaction notes

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