Acetone → HCID 67581944, compound

Participants

Reaction Steps

4-[(1S,2S)-(2-Hydroxycyclopentan-1-yl)oxy]-2-(1-piperazinyl)quinazoline (cf. Example 5) (1.03 g) is dissolved in acetone (35 ml) with heating, and the solution is filtered, and to the filtrate is added acetic acid (0.20 ml), and the mixture is allowed to stand at room temperature. The precipitated crystals are separated by filtration to give 4-[(1S,2S)-(2-hydroxycyclopentan-1-yl)oxy]-2-(1-piperazinyl)quinazoline monoacetate (990 mg) as crystals.

Provenance & Evidence