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HRID1416451

反应详情

EQUATION

反应方程式

HRID 1416451 的结构方程式

REACTANTS

反应物

2
结构：CC(=O)O
HCID176

Acetic Acid

C2H4O2

结构：O[C@@H]1CCC[C@H]1Oc1nc(N2CCNCC2)nc2ccccc12
HCID15409126

未命名化合物

PRODUCTS

生成物

1
结构：CC(=O)O.O[C@@H]1CCC[C@H]1Oc1nc(N2CCNCC2)nc2ccccc12
HCID67582936

未命名化合物

收率 58.8%

AUXILIARIES

试剂、催化剂与溶剂

1
结构：CC(C)=O
溶剂HCID180

Acetone

C3H6O

PROCEDURE

实验过程

4-[(1R,2R)-(2-Hydroxycyclopentan-1-yl)oxy]-2-(1-piperazinyl)quinazoline (cf. Example 7) (1.1 g) is dissolved in acetone (30 ml), and thereto is added acetic acid (0.23 g). The precipitated crystals are separated by filtration and recrystallized from acetone to give 4-[(1R,2R)-(2-hydroxycyclopentan-1-yl)oxy]-2-(1-piperazinyl)quinazoline monoacetate (0.77 g).

WORKUP

后处理

  1. customThe precipitated crystals are separated by filtration
  2. customrecrystallized from acetone