HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetic Acid → 4-[trans-(2-Hydroxycyclopentan-1-yl)oxy]-2-(1-piperazinyl)quinazoline monoacetate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetic Acid | HCID 176 | — |
| Reactant | 4-[trans-(2-Hydroxycyclopentan-1-yl)oxy]-2-(1-piperazinyl)quinazoline | HCID 15409126 | — |
| Solvent | Acetone | HCID 180 | — |
| Product | 4-[trans-(2-Hydroxycyclopentan-1-yl)oxy]-2-(1-piperazinyl)quinazoline monoacetate | HCID 67582936 | 58.8% |
Reaction Steps
4-[(1R,2R)-(2-Hydroxycyclopentan-1-yl)oxy]-2-(1-piperazinyl)quinazoline (cf. Example 7) (1.1 g) is dissolved in acetone (30 ml), and thereto is added acetic acid (0.23 g). The precipitated crystals are separated by filtration and recrystallized from acetone to give 4-[(1R,2R)-(2-hydroxycyclopentan-1-yl)oxy]-2-(1-piperazinyl)quinazoline monoacetate (0.77 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05912247 |
| Source dataset | uspto-grants-1999_06 |
| ORD ID | ord-ce76b2f81a9c4e598bc2c87c0bc5acbe |
| Source note | uspto-grants-1999_06 |