Hydrochloride methanol → HCID 67581958, compound

HRID 1416455Notes

Reaction equation

HRID 1416455 reaction equation
C(O)(=O)C.[OH:5][C@@H:6]1[CH2:10][O:9][CH2:8][C@H:7]1[O:11][C:12]1[C:21]2[C:16](=[CH:17][CH:18]=[CH:19][CH:20]=2)[N:15]=[C:14]([N:22]2[CH2:27][CH2:26][NH:25][CH2:24][CH2:23]2)[N:13]=1.[ClH:28].CO>CC(C)=O>[ClH:28].[OH:5][C@@H:6]1[CH2:10][O:9][CH2:8][C@H:7]1[O:11][C:12]1[C:21]2[C:16](=[CH:17][CH:18]=[CH:19][CH:20]=2)[N:15]=[C:14]([N:22]2[CH2:23][CH2:24][NH:25][CH2:26][CH2:27]2)[N:13]=1

Participants

4

Reactant 2

HCID 21893726Hydrochloride methanolHCID 67582065HCID 67582065, compound

Product 1

HCID 67581958HCID 67581958, compound

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Procedure

To a solution of 4-[trans-(4-hydroxytetrahydrofuran-3-yl)oxy]-2-(1-piperazinyl)quinazoline monoacetate (cf. Example 12) (150 mg) in acetone (10 ml) is added 2N HCl-methanol (0.26 ml), and the mixture is evaporated to dryness under reduced pressure, and the residue is washed with acetone. The obtained crystals are recrystallized from methanol-acetone to give 4-[trans-(4-hydroxytetrahydrofuran-3-yl)oxy]-2-(1-piperazinyl) quinazoline monohydrochloride (96 mg) as crystals.

Workup

  1. customthe mixture is evaporated to dryness under reduced pressure
  2. washthe residue is washed with acetone
  3. customThe obtained crystals are recrystallized from methanol-acetone

Sources & evidence

ORD record
ord-37481a127b8f47adb575f9c5a5dd5052
Source dataset
uspto-grants-1999_06
Patent number
US05912247

Reaction notes

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