Hydrochloride methanol → HCID 67581958, compound

Participants

Reaction Steps

To a solution of 4-[trans-(4-hydroxytetrahydrofuran-3-yl)oxy]-2-(1-piperazinyl)quinazoline monoacetate (cf. Example 12) (150 mg) in acetone (10 ml) is added 2N HCl-methanol (0.26 ml), and the mixture is evaporated to dryness under reduced pressure, and the residue is washed with acetone. The obtained crystals are recrystallized from methanol-acetone to give 4-[trans-(4-hydroxytetrahydrofuran-3-yl)oxy]-2-(1-piperazinyl) quinazoline monohydrochloride (96 mg) as crystals.

Provenance & Evidence