Hydrochloride methanol → HCID 67581998, compound

HRID 1416459Notes

Reaction equation

HRID 1416459 reaction equation
C(O)(=O)C.[OH:5][C@H:6]1[CH2:10][O:9][CH2:8][C@@H:7]1[O:11][C:12]1[C:21]2[C:16](=[CH:17][CH:18]=[CH:19][CH:20]=2)[N:15]=[C:14]([N:22]2[CH2:27][CH2:26][NH:25][CH2:24][CH2:23]2)[N:13]=1.[ClH:28].CO>CO>[ClH:28].[OH:5][C@H:6]1[CH2:10][O:9][CH2:8][C@@H:7]1[O:11][C:12]1[C:21]2[C:16](=[CH:17][CH:18]=[CH:19][CH:20]=2)[N:15]=[C:14]([N:22]2[CH2:23][CH2:24][NH:25][CH2:26][CH2:27]2)[N:13]=1

Participants

4

Reactant 2

HCID 21893726Hydrochloride methanolHCID 67582012HCID 67582012, compound

Product 1

HCID 67581998HCID 67581998, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To a solution of 4-[(3S,4S)-(4-hydroxytetrahydrofuran-3-yl)oxy]-2-(1-piperazinyl)quinazoline monoacetate (cf. Example 17) (1.54 g) in methanol (44 ml) is added 2N HCl-methanol (2.25 ml), and the mixture is evaporated to dryness under reduced pressure. The residue is washed with acetone and recrystallized from methanol-acetone to give 4-[(3S,4S)-(4-hydroxytetrahydrofuran-3-yl)oxy]-2-(1-piperazinyl)quinazoline monohydrochloride (775 mg) as crystals.

Workup

  1. customthe mixture is evaporated to dryness under reduced pressure
  2. washThe residue is washed with acetone
  3. customrecrystallized from methanol-acetone

Sources & evidence

ORD record
ord-41a28eb32bfc4e5c80ce10e4aa4da51e
Source dataset
uspto-grants-1999_06
Patent number
US05912247

Reaction notes

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