Hydrochloride methanol → HCID 67581998, compound

Participants

Reaction Steps

To a solution of 4-[(3S,4S)-(4-hydroxytetrahydrofuran-3-yl)oxy]-2-(1-piperazinyl)quinazoline monoacetate (cf. Example 17) (1.54 g) in methanol (44 ml) is added 2N HCl-methanol (2.25 ml), and the mixture is evaporated to dryness under reduced pressure. The residue is washed with acetone and recrystallized from methanol-acetone to give 4-[(3S,4S)-(4-hydroxytetrahydrofuran-3-yl)oxy]-2-(1-piperazinyl)quinazoline monohydrochloride (775 mg) as crystals.

Provenance & Evidence