Ethanol → HCID 57098847, compound

HRID 1416463Notes

Reaction equation

HRID 1416463 reaction equation
[OH:1][C@@H:2]1[CH2:6][O:5][CH2:4][C@H:3]1[O:7][C:8]1[C:17]2[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=2)[N:11]=[C:10]([N:18]2[CH2:23][CH2:22][NH:21][CH2:20][CH2:19]2)[N:9]=1.[C:24]([OH:31])(=O)/C=C/C(O)=O.[CH2:32](O)C>>[OH:1][C@H:2]1[C@@H:6]([OH:5])[C@H:32]([O:31][CH3:24])[CH2:4][C@@H:3]1[O:7][C:8]1[C:17]2[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=2)[N:11]=[C:10]([N:18]2[CH2:19][CH2:20][NH:21][CH2:22][CH2:23]2)[N:9]=1

Participants

4

Reactant 3

HCID 702EthanolHCID 444972Fumaric AcidHCID 54489989HCID 54489989, compound

Product 1

HCID 57098847HCID 57098847, compound

Procedure

4-[(3R,4R)-(4-Hydroxytetrahydrofuran-3-yl)oxy]-2-(1-piperazinyl)quinazoline (cf. Example 19) (499 mg) and fumaric acid (192 mg) are dissolved in ethanol (20ml), and the mixture is allowed to stand at room temperature. The precipitated crystals are separated by filtration, and recrystallized from water-acetone to give 4-[(3R,4R)-(4-hydroxytetrahydrofuran-3-yl)oxy]-2-(1-piperazinyl) quinazoline 1/2 fumarate (462 mg) as crystals.

Workup

  1. customto stand at room temperature
  2. customThe precipitated crystals are separated by filtration
  3. customrecrystallized from water-acetone

Sources & evidence

ORD record
ord-42a0ef24168d4966889ccf5d18a97cac
Source dataset
uspto-grants-1999_06
Patent number
US05912247

Reaction notes

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