HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethanol → HCID 57098847, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethanol | HCID 702 | — |
| Reactant | Fumaric Acid | HCID 444972 | — |
| Reactant | HCID 54489989 | HCID 54489989 | — |
| Product | HCID 57098847 | HCID 57098847 | — |
Reaction Steps
4-[(3R,4R)-(4-Hydroxytetrahydrofuran-3-yl)oxy]-2-(1-piperazinyl)quinazoline (cf. Example 19) (499 mg) and fumaric acid (192 mg) are dissolved in ethanol (20ml), and the mixture is allowed to stand at room temperature. The precipitated crystals are separated by filtration, and recrystallized from water-acetone to give 4-[(3R,4R)-(4-hydroxytetrahydrofuran-3-yl)oxy]-2-(1-piperazinyl) quinazoline 1/2 fumarate (462 mg) as crystals.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05912247 |
| Source dataset | uspto-grants-1999_06 |
| ORD ID | ord-42a0ef24168d4966889ccf5d18a97cac |
| Source note | uspto-grants-1999_06 |