Acetic Acid → HCID 67582082, compound

HRID 1416485Notes

Reaction equation

HRID 1416485 reaction equation
[OH:1][CH:2]([CH2:21][OH:22])[CH2:3][O:4][C:5]1[C:14]2[C:9](=[CH:10][CH:11]=[CH:12][CH:13]=2)[N:8]=[C:7]([N:15]2[CH2:20][CH2:19][NH:18][CH2:17][CH2:16]2)[N:6]=1.[C:23]([OH:26])(=[O:25])[CH3:24]>CC(C)=O.CO>[C:23]([OH:26])(=[O:25])[CH3:24].[OH:1][CH:2]([CH2:21][OH:22])[CH2:3][O:4][C:5]1[C:14]2[C:9](=[CH:10][CH:11]=[CH:12][CH:13]=2)[N:8]=[C:7]([N:15]2[CH2:16][CH2:17][NH:18][CH2:19][CH2:20]2)[N:6]=1

Participants

4

Reactant 2

HCID 176Acetic AcidHCID 53831111HCID 53831111, compound

Product 1

HCID 67582082HCID 67582082, compoundYield 66%

Reagents, catalysts & solvents 1

HCID 21894497Aceton-methanolSolvent

Procedure

To a solution of 4-[(RS)-(2,3-dihydroxypropyl)oxy]-2-(1-piperazinyl)quinazoline (cf. Example 44) (300 mg) in acetone-methanol is added acetic acid (65 mg), and the mixture is filtered, and the filtrate is evaporated to dryness under reduced pressure. The residue is recrystallized from methanol-acetone to give 4-[(RS)-(2,3-dihydroxypropyl)oxy]-2-(1-piperazinyl)quinazoline monoacetate (237 mg) as crystals.

Workup

  1. filtrationthe mixture is filtered
  2. customthe filtrate is evaporated to dryness under reduced pressure
  3. customThe residue is recrystallized from methanol-acetone

Sources & evidence

ORD record
ord-af1c022c890e4284b89dc7ea352178bb
Source dataset
uspto-grants-1999_06
Patent number
US05912247

Reaction notes

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