HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetic Acid → HCID 67582082, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetic Acid | HCID 176 | — |
| Reactant | HCID 53831111 | HCID 53831111 | — |
| Solvent | Aceton-methanol | HCID 21894497 | — |
| Product | HCID 67582082 | HCID 67582082 | 66% |
Reaction Steps
To a solution of 4-[(RS)-(2,3-dihydroxypropyl)oxy]-2-(1-piperazinyl)quinazoline (cf. Example 44) (300 mg) in acetone-methanol is added acetic acid (65 mg), and the mixture is filtered, and the filtrate is evaporated to dryness under reduced pressure. The residue is recrystallized from methanol-acetone to give 4-[(RS)-(2,3-dihydroxypropyl)oxy]-2-(1-piperazinyl)quinazoline monoacetate (237 mg) as crystals.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05912247 |
| Source dataset | uspto-grants-1999_06 |
| ORD ID | ord-af1c022c890e4284b89dc7ea352178bb |
| Source note | uspto-grants-1999_06 |