Acetic Acid → HCID 67581954, compound

HRID 1416486Notes

Reaction equation

HRID 1416486 reaction equation
[OH:1][CH:2]([CH3:22])[CH:3]([O:5][C:6]1[C:15]2[C:10](=[CH:11][CH:12]=[CH:13][CH:14]=2)[N:9]=[C:8]([N:16]2[CH2:21][CH2:20][NH:19][CH2:18][CH2:17]2)[N:7]=1)[CH3:4].[C:23]([OH:26])(=[O:25])[CH3:24]>CC(C)=O>[C:23]([OH:26])(=[O:25])[CH3:24].[OH:1][CH:2]([CH3:22])[CH:3]([O:5][C:6]1[C:15]2[C:10](=[CH:11][CH:12]=[CH:13][CH:14]=2)[N:9]=[C:8]([N:16]2[CH2:17][CH2:18][NH:19][CH2:20][CH2:21]2)[N:7]=1)[CH3:4]

Participants

4

Reactant 2

HCID 176Acetic AcidHCID 67581955HCID 67581955, compound

Product 1

HCID 67581954HCID 67581954, compoundYield 66.5%

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Procedure

To a suspension of 4-[(2RS,3SR)-(3-hydroxybutan-2-yl)oxy]-2-(1-piperazinyl)quinazoline (cf. Example 46) (600 mg) in acetone (20 ml) is added acetic acid (136 mg), and the mixture is filtered, and the filtrate is allowed to stand at room temperature, and the precipitated crystals are separated by filtration to give 4-[(2RS,3SR)-(3-hydroxybutan-2-yl)oxy]-2-(1-piperazinyl)quinazoline monoacetate (478 mg) as crystals.

Workup

  1. filtrationthe mixture is filtered
  2. customto stand at room temperature
  3. customthe precipitated crystals are separated by filtration

Sources & evidence

ORD record
ord-6d7648c7da684b019e22dc87b1fc91b3
Source dataset
uspto-grants-1999_06
Patent number
US05912247

Reaction notes

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