Hydrochloride methanol → HCID 67582048, compound

HRID 1416494Notes

Reaction equation

HRID 1416494 reaction equation
[OH:1][C@@H:2]([C@H:21]([OH:23])[CH3:22])[CH2:3][O:4][C:5]1[C:14]2[C:9](=[CH:10][CH:11]=[CH:12][CH:13]=2)[N:8]=[C:7]([N:15]2[CH2:20][CH2:19][NH:18][CH2:17][CH2:16]2)[N:6]=1.[ClH:24].CO>CO>[ClH:24].[OH:1][C@@H:2]([C@H:21]([OH:23])[CH3:22])[CH2:3][O:4][C:5]1[C:14]2[C:9](=[CH:10][CH:11]=[CH:12][CH:13]=2)[N:8]=[C:7]([N:15]2[CH2:16][CH2:17][NH:18][CH2:19][CH2:20]2)[N:6]=1

Participants

4

Reactant 2

HCID 21893726Hydrochloride methanolHCID 54302337HCID 54302337, compound

Product 1

HCID 67582048HCID 67582048, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

4-[(2R,3R)-(2,3-Dihydroxybutan-1-yl)oxy]-2-(1-piperazinyl)quinazoline (cf. Example 55) (0.85 g) is dissolved in methanol (10 ml), and thereto is added 2N HCl-methanol (1.6 ml), and the mixture is evaporated to dryness under reduced pressure. The resulting residue is recrystallized from ethanol to give 4-[(2R,3R)-(2,3-dihydroxybutan-1-yl)oxy]-2-(1-piperazinyl)quinazoline monohydrochloride (0.3 g).

Workup

  1. customthe mixture is evaporated to dryness under reduced pressure
  2. customThe resulting residue is recrystallized from ethanol

Sources & evidence

ORD record
ord-7b3bbd62f6174f178d64a52c98e44f8a
Source dataset
uspto-grants-1999_06
Patent number
US05912247

Reaction notes

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