Hydrochloride methanol → HCID 67583546, compound

HRID 1416498Notes

Reaction equation

HRID 1416498 reaction equation
[OH:1][C@H:2]([CH2:22][OH:23])[CH2:3][CH2:4][O:5][C:6]1[C:15]2[C:10](=[CH:11][CH:12]=[CH:13][CH:14]=2)[N:9]=[C:8]([N:16]2[CH2:21][CH2:20][NH:19][CH2:18][CH2:17]2)[N:7]=1.[ClH:24].CO>CO>[ClH:24].[OH:1][C@H:2]([CH2:22][OH:23])[CH2:3][CH2:4][O:5][C:6]1[C:15]2[C:10](=[CH:11][CH:12]=[CH:13][CH:14]=2)[N:9]=[C:8]([N:16]2[CH2:17][CH2:18][NH:19][CH2:20][CH2:21]2)[N:7]=1

Participants

4

Reactant 2

HCID 21893726Hydrochloride methanolHCID 57109376HCID 57109376, compound

Product 1

HCID 67583546HCID 67583546, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To a solution of 4-[(3S)-(3,4-dihydroxybutan-1-yl)oxy]-2-(1-piperazinyl)quinazoline (cf. Example 57) (1.00 g) in methanol (20 ml) is added 2N HCl-methanol (1.89 ml), and the mixture is evaporated to dryness under reduced pressure. The resulting residue is washed with acetone and recrystallized from methanol-acetone to give 4-[(3S)-(3,4-dihydroxybutan-1-yl)oxy]-2-(1-piperazinyl)quinazoline monohydrochloride (697 mg) as crystals.

Workup

  1. customthe mixture is evaporated to dryness under reduced pressure
  2. washThe resulting residue is washed with acetone
  3. customrecrystallized from methanol-acetone

Sources & evidence

ORD record
ord-99d7dcddc22a432caa428e26dc0fe147
Source dataset
uspto-grants-1999_06
Patent number
US05912247

Reaction notes

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