Hydrochloride methanol → HCID 67583546, compound

Participants

Reaction Steps

To a solution of 4-[(3S)-(3,4-dihydroxybutan-1-yl)oxy]-2-(1-piperazinyl)quinazoline (cf. Example 57) (1.00 g) in methanol (20 ml) is added 2N HCl-methanol (1.89 ml), and the mixture is evaporated to dryness under reduced pressure. The resulting residue is washed with acetone and recrystallized from methanol-acetone to give 4-[(3S)-(3,4-dihydroxybutan-1-yl)oxy]-2-(1-piperazinyl)quinazoline monohydrochloride (697 mg) as crystals.

Provenance & Evidence