Ethanol → HCID 15858809, compound

HRID 1416539Notes

Reaction equation

HRID 1416539 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([S:8]([C:11]([CH3:16])=[CH:12]OCC)(=[O:10])=[O:9])=[CH:4][CH:3]=1.[NH2:17][OH:18].[CH2:19](O)C>O>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([S:8]([C:11]2[CH:16]=[N:17][O:18][C:12]=2[CH3:19])(=[O:9])=[O:10])=[CH:6][CH:7]=1

Participants

5

Reactant 3

HCID 702EthanolHCID 787HydroxylamineHCID 54563386HCID 54563386, compound

Product 1

HCID 15858809HCID 15858809, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

A 10 gram suspension of 2-(4-chlorophenylsulfonyl)-1-ethoxypropene in 30 ml of ethanol was added with a solution of 1.1 equivalent of hydroxylamine in 20 ml of water. The mixture was then stirred at room temperature for 2 hours, chilled in an ice-water bath for 30 minutes and filtered. The resulting solid was crystallized in ethanol and water to provide 8.0 grams of 4-(4-chlorophenylsulfonyl)-5-methylisoxazole.

Workup

  1. temperaturechilled in an ice-water bath for 30 minutes
  2. filtrationfiltered
  3. customThe resulting solid was crystallized in ethanol

Sources & evidence

ORD record
ord-5957fc93e7d44fa98d280f9f1d34fb2a
Source dataset
uspto-grants-1999_06
Patent number
US05914343

Reaction notes

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