反应详情

A reaction mixture of N-[4-chloro-3-[dimethylhydrazono)methyl]phenyl]-2-methyl 3-furancarboxamide (1 g), sodium bicarbonate (1.8 g) and Lawesson's reagent (0.9 g) in toluene (20 mL) was refluxed for 3 hours. The reaction mixture was then cooled and filtered through a plug of neutral aluminum oxide and eluted with ether. Evaporation of the solvent produced 0.6 g of N-[4-chloro-3-[dimethylhydrazono)methyl]phenyl]-2-methyl-3-furancarbothioamide, m.p. 90-92° C.

1. temperaturewas refluxed for 3 hours
2. temperatureThe reaction mixture was then cooled
3. filtrationfiltered through a plug of neutral aluminum oxide
4. washeluted with ether
5. customEvaporation of the solvent