反应详情

温度

85 °C

A reaction mixture of N-[4-chloro-3-[(4-morpholinylimino)methyl]phenyl]-2-methyl-3-furancarboxamide (1.0 g), sodium bicarbonate (2.5 g), Lawesson's reagent (1.2 g) in toluene (25 ml) was heated at 85° C. for 4 hours. After cooling, the reaction mixture was passed through a plug of aluminum oxide, followed by elution with ether. Evaporation of the eluant gave 0.5 g of N-[4-chloro-3-[(4-morpholinylimino)methyl]phenyl]-2-methyl-3-furancarbothioamide as a yellow solid, mp 142-143° C.

1. temperatureAfter cooling
2. washfollowed by elution with ether
3. customEvaporation of the eluant