Hydrochloric Acid → HCID 21309685, compound

HRID 1416614Notes

Reaction equation

HRID 1416614 reaction equation
[CH3:1][O:2][CH:3]1[CH2:7][N:6]([CH3:8])[C@H:5]([CH2:9][O:10][C:11]2[CH:12]=[N:13][CH:14]=[CH:15][CH:16]=2)[CH2:4]1.[ClH:17]>CCOCC>[ClH:17].[ClH:17].[CH3:1][O:2][CH:3]1[CH2:7][N:6]([CH3:8])[C@H:5]([CH2:9][O:10][C:11]2[CH:12]=[N:13][CH:14]=[CH:15][CH:16]=2)[CH2:4]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 21309686HCID 21309686, compound

Product 1

HCID 21309685HCID 21309685, compound

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

The compound from step 47b was treated with HCl in ether according to Example 14c to afford the title compound. MS (DCI/NH3) m/e: 223 (M+H)+. 1H NMR (D2O, 300 MHz) δ: 8.61 (m, 1H), 8.43 (d, 1H, J=5.32 Hz), 7.91 (m, 1H), 7.74 dd, 1H, J=5.34, 8.1 Hz), 4.61-4.53 (m, 2H), 4.14 (m, 1H), 3.98 (m, 1H), 3.81 (m, 1H), 3.30 (s, 3H), 3.22 (m, 1H), 2.96 (s, 3H), 2.37 (m, 1H), 2.01 (m, 1H). Anal. Calc. for C12H20N2O2Cl2 : C, 48.82; H, 6.82; N, 9.49; Found C, 48.56; H, 6.88; N, 9.43.

Sources & evidence

ORD record
ord-a541c83f0a654200a3d14d756fbc2717
Source dataset
uspto-grants-1999_06
Patent number
US05914328

Reaction notes

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