HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-Hydroxypyridine → 1-BOC-2-(R)-azetidinylmethoxy pyridine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-Hydroxypyridine | HCID 7971 | — |
| Reactant | Triphenylphosphine | HCID 11776 | — |
| Reactant | Diethyl azodicarboxylate | HCID 5462977 | — |
| Reactant | (R)-1-Boc-2-azetidinemethanol | HCID 11074142 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 1-BOC-2-(R)-azetidinylmethoxy pyridine | HCID 67585371 | — |
Reaction Steps
A 1.10 g (5.87 mmol) sample of 1-BOC-2-(R)-azetidinemethanol, prepared in step 62b above, and 588 g (5.87 mmol) of 3-hydroxypyridine were reacted with triphenylphosphine and DEAD (7.05 mmol each) in 100 mL of THF according to the procedure of Example 14a, to give the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05914328 |
| Source dataset | uspto-grants-1999_06 |
| ORD ID | ord-16551dd045a1450f80644941dd943e50 |
| Source note | uspto-grants-1999_06 |