Sodium Methoxide → 3-((1-methyl-2-(S)-pyrrolidinyl)methoxy)-5methoxy-pyridine-N-oxide

HRID 1416654Notes

Reaction equation

HRID 1416654 reaction equation
[CH3:1][N:2]1[CH2:6][CH2:5][CH2:4][C@H:3]1[CH2:7][O:8][C:9]1[CH:10]=[N+:11]([O-:16])[CH:12]=[C:13](Br)[CH:14]=1.[CH3:17][O-:18].[Na+]>CO>[CH3:1][N:2]1[CH2:6][CH2:5][CH2:4][C@H:3]1[CH2:7][O:8][C:9]1[CH:10]=[N+:11]([O-:16])[CH:12]=[C:13]([O:18][CH3:17])[CH:14]=1

Participants

4

Reactant 2

HCID 10942334Sodium MethoxideHCID 213096723-Bromo-5-((S)-1-methyl-pyrrolidin-2-ylmethoxy)-pyridine 1-oxide

Product 1

HCID 213096733-((1-methyl-2-(S)-pyrrolidinyl)methoxy)-5methoxy-pyridine-N-oxide

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A sample of the compound from step 98a above is reacted with sodium methoxide in methanol according to standard procedures. The reaction is quenched with water, the product is extracted, then purified by chromatography on silica gel.

Workup

  1. customThe reaction is quenched with water
  2. extractionthe product is extracted
  3. custompurified by chromatography on silica gel

Sources & evidence

ORD record
ord-1d450716c2c64c538c2ac86dc76cce6f
Source dataset
uspto-grants-1999_06
Patent number
US05914328

Reaction notes

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