反应详情

1-(2-methylphenyl)-4-oxo-6-methyl-4,5-dihydro pyrrolo[3,2-c]quinoline (1.16 g, 4.0 mmol) was dissolved in 10 ml of phosphoryl chloride (POCl3) and heated for 2 hours. The reaction mixture was stirred at room temperature for 30 minutes after cooling and addition of ice water. The reaction mixture was extracted with methylene chloride (20 ml×3). After washing with water (15 ml×3), the organic layer was dried by anhydrous magnesium sulfate and filtered, and concentrated under reduced pressure. The residue was purified by silica gel chromatography to obtain 1.12 g of desired compound as an oil in 91% of yield.

1. temperatureheated for 2 hours
2. temperatureafter cooling
3. extractionThe reaction mixture was extracted with methylene chloride (20 ml×3)
4. washAfter washing with water (15 ml×3)
5. dry with materialthe organic layer was dried by anhydrous magnesium sulfate
6. filtrationfiltered
7. concentrationconcentrated under reduced pressure
8. customThe residue was purified by silica gel chromatography