1-Pentanol → HCID 9894072, compound

Participants

Reaction Steps

The title compound was prepared from 5-{2-[2-(3-chloro-phenyl)-2-hydroxy-ethylamino]-propyl}-benzo[1,3]dioxole-2,2-dicarboxylic acid and 1-pentanol as a brown gum according to the procedure of Example 1, leaving out the final HCl(g) /Et2O hydrochloride salt forming step: 1H NMR (300 MHz, CDCl3): δ 0.90 (t, J=6.9 Hz, 3H), 1.21-1.41 (brm, 10H), 1.67 (t, J=7.0 Hz, 4H), 1.80-2.10 (brs, 1H), 2.80 (t, J=6.5 Hz, 1H), 3.05-3.19 (brm, 2H), 3.45 (d, J=10.4 Hz, 2H), 4.28 (t, J=6.7 Hz, 4H), 5.46 (d, J=9.6 Hz, 1H), 5.50-5.90 (brs, 1H), 6.71-6.90 (m, 3H), 7.20-7.35 (m, 3H), 7.43 (s, 1H), 8.76 (brs, 1H), 1.05 (brs, 1H); MS (ES) m/z (relative intensity): 562 (M+, 100).

Provenance & Evidence