1-Pentanol → HCID 9894072, compound

HRID 1416731Notes

Reaction equation

[Cl:1][C:2]1[CH:3]=[C:4]([CH:8]([OH:29])[CH2:9][NH:10][CH:11]([CH3:28])[CH2:12][C:13]2[CH:27]=[CH:26][C:16]3[O:17][C:18]([C:23]([OH:25])=[O:24])([C:20]([OH:22])=[O:21])[O:19][C:15]=3[CH:14]=2)[CH:5]=[CH:6][CH:7]=1.[CH2:30](O)[CH2:31][CH2:32][CH2:33][CH3:34]>>[CH2:30]([O:24][C:23]([C:18]1([C:20]([O:22][CH2:6][CH2:7][CH2:2][CH2:3][CH3:4])=[O:21])[O:17][C:16]2[CH:26]=[CH:27][C:13]([CH2:12][CH:11]([NH:10][CH2:9][CH:8]([C:4]3[CH:5]=[CH:6][CH:7]=[C:2]([Cl:1])[CH:3]=3)[OH:29])[CH3:28])=[CH:14][C:15]=2[O:19]1)=[O:25])[CH2:31][CH2:32][CH2:33][CH3:34].[O:17]([CH2:18][CH3:20])[CH2:16][CH3:15].[ClH:1]

Participants

Reactant 2

HCID 62761-Pentanol

HCID 42813555-{2-[2-(3-Chloro-phenyl)-2-hydroxy-ethylamino]-propyl}-benzo[1,3]dioxole-2,2-dicarboxylic acid

Product 2

HCID 9894072HCID 9894072, compound

HCID 10953452Ether hydrochloride

Procedure

The title compound was prepared from 5-{2-[2-(3-chloro-phenyl)-2-hydroxy-ethylamino]-propyl}-benzo[1,3]dioxole-2,2-dicarboxylic acid and 1-pentanol as a brown gum according to the procedure of Example 1, leaving out the final HCl(g) /Et2O hydrochloride salt forming step: 1H NMR (300 MHz, CDCl3): δ 0.90 (t, J=6.9 Hz, 3H), 1.21-1.41 (brm, 10H), 1.67 (t, J=7.0 Hz, 4H), 1.80-2.10 (brs, 1H), 2.80 (t, J=6.5 Hz, 1H), 3.05-3.19 (brm, 2H), 3.45 (d, J=10.4 Hz, 2H), 4.28 (t, J=6.7 Hz, 4H), 5.46 (d, J=9.6 Hz, 1H), 5.50-5.90 (brs, 1H), 6.71-6.90 (m, 3H), 7.20-7.35 (m, 3H), 7.43 (s, 1H), 8.76 (brs, 1H), 1.05 (brs, 1H); MS (ES) m/z (relative intensity): 562 (M+, 100).

Sources & evidence

ORD record: ord-36cc777c8a0040019f518ded01c0e561
Source dataset: uspto-grants-1999_06
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05914339

Reaction notes

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