反应详情

The title compound was prepared from 5-{2-[2-(3-chloro-phenyl)-2-hydroxy-ethylamino]-propyl}-benzo[1,3]dioxole-2,2-dicarboxylic acid and cyclopropylmethanol according to the procedure of Example 1 as an off-white solid; 1H NMR (DMSO) δ 0.25 (q,2H), 0.49 (q,2H), 1.01 (d,3H), 1.10 (m,1H), 2.49 (m, 1H), 2.85-3.20 (m,4H), 3.94 (d, 2H) 4.85 (bt, 1H), 6.58 (d, 1H), 6.76 (m,2H), 7.35(m,3H), 7.46(s,1H); IR (KBr): 1653 cm-1 (C=O), 1747 cm-1 (C=O); MS (CI) m/z 476 (MH+). Anal. Calcd. for C24H26ClNO7 : C, 60.57; H, 5.51; N, 2.94; Cl, 7.46. Found: C, 56.38; H, 5.16; N, 2.61; Cl, 7.60.