HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ammonia → 3-Carbamoyl-4-chloro-8-nitroquinoline
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ammonia | HCID 222 | — |
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Reactant | 3-Carboxy-8-nitro-4-oxo-3,4-dihydroquinoline | HCID 21250024 | — |
| Product | 3-Carbamoyl-4-chloro-8-nitroquinoline | HCID 21250101 | 79% |
Reaction Steps
Using an analogous procedure to that described in Example 2 in the section relating to the preparation of starting materials 3-carboxy-8-nitro-4-oxo-3,4-dihydroquinoline was reacted with thionyl chloride and then concentrated aqueous ammonia. The product so obtained was recrystallised from ethanol to give 3-carbamoyl-4-chloro-8-nitroquinoline in 79% yield, mp 277-279° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05916898 |
| Source dataset | uspto-grants-1999_06 |
| ORD ID | ord-05220bd29d454518bf1f108e7f36efc1 |
| Source note | uspto-grants-1999_06 |