Hydrazine hydrate (1:1) → HCID 54536790, compound

HRID 1417137Notes

Reaction equation

HRID 1417137 reaction equation
F[C:2]1[CH:7]=[CH:6][C:5]([NH:8][C:9](=[O:37])[CH:10]([O:20][C:21]2[CH:26]=[CH:25][C:24]([S:27]([C:30]3[CH:35]=[CH:34][C:33]([OH:36])=[CH:32][CH:31]=3)(=[O:29])=[O:28])=[CH:23][CH:22]=2)[CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH3:19])=[CH:4][C:3]=1[N+:38]([O-:40])=[O:39].O.[NH2:42][NH2:43]>CS(C)=O>[NH:42]([C:2]1[CH:7]=[CH:6][C:5]([NH:8][C:9](=[O:37])[CH:10]([O:20][C:21]2[CH:26]=[CH:25][C:24]([S:27]([C:30]3[CH:35]=[CH:34][C:33]([OH:36])=[CH:32][CH:31]=3)(=[O:29])=[O:28])=[CH:23][CH:22]=2)[CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH3:19])=[CH:4][C:3]=1[N+:38]([O-:40])=[O:39])[NH2:43]

Participants

4

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 54151890HCID 54151890, compound

Product 1

HCID 54536790HCID 54536790, compound

Reagents, catalysts & solvents 1

HCID 679Dimethyl SulfoxideSolvent

Procedure

N-(4-Fluoro-3-nitrophenyl)-2-[4-(4-hydroxyphenylsulphonyl)-phenoxy]undecylamide (86.0 g, 147.0 mmole) was dissolved in dimethyl sulphoxide (500 ml), and hydrazine monohydrate (17.8 g, 355 mmole) was added in a dropwise fashion whilst keeping the temperature below 40° C. The reaction mixture was stirred for 1.5 hr at room temperature, and was then drowned in an ice/brine mixture (61). The red solid obtained was filtered off and dried at room temperature. The product was used in this crude form without any further purification.

Workup

  1. customthe temperature below 40° C
  2. customThe red solid obtained
  3. filtrationwas filtered off
  4. customdried at room temperature
  5. customwithout any further purification

Sources & evidence

ORD record
ord-b6720fe6f23b4affbf5617ae5fbb5524
Source dataset
uspto-grants-1999_03
Patent number
US05876912

Reaction notes

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