Trifluoroacetic acid → HCID 86753786, compound

HRID 1417187Notes

Reaction equation

HRID 1417187 reaction equation
C([O:5][C:6](=[O:21])[C:7]1[CH:12]=[CH:11][C:10]([C:13]([NH2:20])=[N:14][O:15][C:16]([O:18][CH3:19])=[O:17])=[CH:9][CH:8]=1)(C)(C)C.[F:22][C:23]([F:28])([F:27])[C:24]([OH:26])=[O:25]>>[F:22][C:23]([F:28])([F:27])[C:24]([OH:26])=[O:25].[NH2:20][C:13](=[N:14][O:15][C:16]([O:18][CH3:19])=[O:17])[C:10]1[CH:9]=[CH:8][C:7]([C:6]([OH:21])=[O:5])=[CH:12][CH:11]=1

Participants

3

Reactant 2

HCID 6422Trifluoroacetic acidHCID 53801236HCID 53801236, compound

Product 1

HCID 86753786HCID 86753786, compound

Procedure

In 4.0 ml of trifluoroacetic acid was dissolved 1.0 g of 4-(amino-methoxycarbonyloxyiminomethyl)benzoic acid t-butyl ester. The solution was stirred for one hour at room temperature. The reaction mixture was concentrated under reduced pressure. The concentrate was subjected to azeotropic distillation with toluene to afford 0.80 g of the title compound as a colorless amorphous powdery product.

Workup

  1. concentrationThe reaction mixture was concentrated under reduced pressure
  2. distillationThe concentrate was subjected to azeotropic distillation with toluene

Sources & evidence

ORD record
ord-db62fdf5c0b64ec2ab485ac3147c03bf
Source dataset
uspto-grants-1999_03
Patent number
US05876756

Reaction notes

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