反应详情

57.4 g of the product from Example 15a were dissolved in 400 ml of tetrahydrofuran and hydrogenated with hydrogen in the presence of 4 g of catalyst (palladium on carbon, 10% by weight) at 30° C. for 5 hours and at 50 bar. The mixture was then filtered, the solvent removed, and the remaining filtrate distilled under a high vacuum. 37 g of product (=63% of theory) were obtained with a boiling point of 83° C. at 0.07 mbar. 19F-NMR: -59.0 and -84.6 ppm; 1H-NMR: 2.98 ppm.

1. filtrationThe mixture was then filtered
2. customthe solvent removed
3. distillationthe remaining filtrate distilled under a high vacuum