HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 10-[4-(1H-Imidazol-1-yl)phenoxy]decaneamine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Hydrazine | HCID 9321 | — |
| Reactant | Tetrafluoro-m-phenylenediamine dihydrochloride | HCID 149026 | — |
| Reactant | 2-[10-[4-(1H-Imidazol-1-yl)phenoxy]decyl]-1H-isoindole-1,3(2H)-dione | HCID 67599358 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 10-[4-(1H-Imidazol-1-yl)phenoxy]decaneamine | HCID 54415265 | — |
Reaction Steps
2-[10-[4-(1H-imidazol-1-yl)phenoxy]decyl]-1H-isoindole-1,3(2H)-dione (Example 65) is converted to the free amino derivative by treatment with hydrazine in a refluxing ethanol solution. A portion is converted to its dihydrochloride salt by treatment with concentrated hydrochloric acid in ethanol to give the desired compound, m.p. 190°-192° C. The free base is obtained by treatment with excess 10N NaOH.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05877196 |
| Source dataset | uspto-grants-1999_03 |
| ORD ID | ord-53d2697f111d4693869bdde0ea7ae1b4 |
| Source note | uspto-grants-1999_03 |